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HOME > Research progress / Achievements > Achievements : Programmed research project 01
Achievements

Programmed research project 01

Molecular mechanism underlying maintenance and differentiation of tissue-specific stem cells
Outline
Research progress
Leader : Atsushi Suzuki

Original Papers

  • Takashima, Y., Terada, M., Kawabata, M., Suzuki, A. Dynamic three-dimensional morphogenesis of intrahepatic bile ducts in mouse liver development. Hepatology 61: 1003-1011, 2015.
  • Miura, S. and Suzuki, A. Rapid cell-fate conversion of mouse fibroblasts into hepatocyte-like cells. Inflamm. Renen. 34: 211-216, 2014.
  • Miura, S. and Suzuki, A. Acquisition of lipid metabolic capability in hepatocyte-like cells directly induced from mouse fibroblasts. Front. Cell Dev. Biol. 2: 1-6, 2014.
  • Sekiya, S. and Suzuki, A. Hepatocytes, rather than cholangiocytes, can be the major source of primitive ductules in the chronically injured mouse liver. Am. J. Pathol. 184: 1468-1478, 2014.
  • Hikichi, T., Matoba, R., Ikeda, T., Watanabe, A., Yamamoto, T., Yoshitake, S., Tamura-Nakano, M., Kimura, T., Kamon, M., Shimura, M., Kawakami, K., Okuda, A., Okochi, H., Inoue, T., Suzuki, A., Masui, S. Transcription factors interfering with dedifferentiation induce cell type-specific transcriptional profiles. Proc. Natl. Acad. Sci. USA. 110: 6412-6417, 2013.
  • Sekiya, S. and Suzuki, A. Intrahepatic cholangiocarcinoma can arise from Notch-mediated conversion of hepatocytes. J. Clin. Invest. 122: 3914-3918, 2012.
  • Sekiya, S. and Suzuki, A. Direct conversion of mouse fibroblasts to hepatocyte-like cells by defined factors. Nature 475: 390-393, 2011.
  • Sekiya, S. and Suzuki, A. Glycogen synthase kinase 3β-dependent Snail degradation directs hepatocyte proliferation in normal liver regeneration. Proc. Natl. Acad. Sci. USA. 108: 11175-11180, 2011.
  • Onoyama, I., Suzuki, A., Matsumoto, A., Tomita, K., Katagiri, H., Oike, Y., Nakayama, K., Nakayama, K.I. Fbxw7 regulates lipid metabolism and cell fate decisions in the mouse liver. J. Clin. Invest. 121: 342-354, 2011.

Review Papers

  • Horisawa, K. and Suzuki, A. Cell-based regenerative therapy for liver disease. Innovative Medicine: Basic Research and Development, Springer Japan (Tokyo), 327-339, 2015.
  • Suzuki, A. Evidence of cell-fate conversion from hepatocytes to cholangiocytes in the injured liver: in vivo genetic lineage-tracing approaches. Curr. Opin. Gastroenterol. 31: 247-251, 2015.
  • Suzuki, A. Liver regeneration: a unique and flexible reaction depending on the type of injury. Genes Cells 20: 77-84, 2015.
  • Suzuki, A. Direct reprogramming. Inflamm. Renen. 34: 209-210, 2014.
  • Suzuki, A. Artificial induction and disease-related conversion of the hepatic fate. Curr. Opin. Genet. Dev. 23: 579-584, 2013.
  • Takashima, Y. and Suzuki, A. Regulation of organogenesis and stem cell properties by T-box transcription factors. Cell. Mol. Life Sci. 70: 3929-3945, 2013.
  Index of Projects Project 02
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