Tubulology (Regulation of Polarity Signaling during Morphogenesis, Remodeling, and Breakdown of Epithelial Tubule Structure)

HOME > Proposed research projects

2014 - 2015

A01

Proposed PRJ01	In Vitro 3D Cultures for Studies on Structural Formation and Regeneration of Intestinal Epithelium	Detail
Leader :	Tetsuya Nakamura

Proposed PRJ02	Regulatory mechanism of de novo lumen formation	Detail
Leader :	Kunihiro Matsumoto

Proposed PRJ03	Molecular mechanisms by which stiffness of extracellular matrix regulates the formation of epithelial tubular structure	Detail
Leader :	Noriyuki Kioka

Proposed PRJ04	Roles of actin-dependent intracellular force in cell-cell communication in epithelial cells	Detail
Leader :	Sawako Yamashiro

Proposed PRJ05	Dissecting the mechanism of epithelial intrinsic tumor suppression through cell-cell communication	Detail
Leader :	Shizue Ohsawa

Proposed PRJ06	Roles of membrane lipids in the epithelial-tube morphogenesis	Detail
Leader :	Junichi Ikenouchi

Proposed PRJ07	Experimental and theoretical approaches to the study of the mesoscopic response to a signaling gradient during branching morphogenesis	Detail
Leader :	Hisako Takigawa-Imamura

Proposed PRJ08	Regulatory mechanisms of cellular dynamics in epithelial tissues	Detail
Leader :	Hiroshi Sasaki

Proposed PRJ09	The mechanism of large tube development of the trachea	Detail
Leader :	Mitsuru Morimoto

Proposed PRJ10	A mechano-chemical coupling mechanism underlying optic cup morphogenesis in embryonic stem cell-derived tissue culture	Detail
Leader :	Mototsugu Eiraku

A02

Proposed PRJ11	Role of cell competition in muti-sequencial carcinogenesis	Detail
Leader :	Shunsuke Kon

Proposed PRJ12	Molecular mechanisms of uterine luminal formation during embryo implantation	Detail
Leader :	Yasushi Hirota

Proposed PRJ13	Intravital multi-dimensional imaging analysis on the liver epithelial tissue dynamics in regeneration and homeostasis	Detail
Leader :	Tohru Itoh

Proposed PRJ14	Molecular mechanism of loss of primary cilia in pancreatic ductal adenocarcinoma cells	Detail
Leader :	Tetsuo Kobayashi

Proposed PRJ15	Cytoskeletal regulation of kidney tubulogenesis in mice and humans	Detail
Leader :	Ryuichi Nishinakamura

Proposed PRJ16	Basement membrane assembly in tubulogenesis	Detail
Leader :	Yamato Kikkawa

Proposed PRJ17	Rotation of a gland in a vessel and its invasion and metastasis	Detail
Leader :	Etsuko Kiyokawa

2012 - 2013

A01

Proposed PRJ01	Study of the cell fate in mammary epithelial tissues, directed by Lgr4, the new modifier of Wnt signaling pathway, and its regulatory role in the cell polarity	Detail
Leader :	Katsuhiko Nishimori

Proposed PRJ02	Single-molecule speckle analysis of actin filament flow at lateral membranes of epithelial cells	Detail
Leader :	Sawako Yamashiro

Proposed PRJ03	Regulatory mechanism of formation and maintenance of epithelial polarity in normal colonic epithelial cells cultured in vitro	Detail
Leader :	Tetsuya Nakamura

Proposed PRJ04	The conversion mechanism of spindle orientation in tubulogenesis	Detail
Leader :	Kunihiro Matsumoto

Proposed PRJ05	Roles of membrane lipids in the epithelial-tube morphogenesis	Detail
Leader :	Junichi Ikenouchi

Proposed PRJ06	Regulation of epithelial tubulogenesis by membrane transport	Detail
Leader :	Shin-ichiro Yoshimura

Proposed PRJ07	Molecular mechanism underlying Aspp1 function in lymphatic vascular formation and maintenance	Detail
Leader :	Masanori Hirashima

Proposed PRJ08	Molecular mechanisms regulating the morphogenesis of bile ducts	Detail
Leader :	Naoki Tanimizu

Proposed PRJ09	Regulation of ciliary signaling pathway that is involved in maintaining the renal tubular structure	Detail
Leader :	Dai Shiba

Proposed PRJ10	Quantitative Analysis of Brain Vesicle Formation by 4D imaging	Detail
Leader :	Kohji Hotta

Proposed PRJ11	Remodeling of the secretory pathway during the formation of cyst and tubule	Detail
Leader :	Nobuhiro Nakamura

Proposed PRJ12	Polarizing mechanism of the seminiferous tubules	Detail
Leader :	Yu Kitadate

Proposed PRJ13	Molecular mechanisms involved in the self-organized optic cup formation in vitro	Detail
Leader :	Mototsugu Eiraku

A02

Proposed PRJ14	Establishment of a mouse model of "cell competition" between transformed and normal epithelial cells in tubular epithelial tissue	Detail
Leader :	Hiroto Katoh

Proposed PRJ15	Development of a novel imaging system in branching morphogenesis of the lung using optical coherence tomography	Detail
Leader :	Hiroyuki Abe

Proposed PRJ16	Establishment of culture system for analyses of biliary tract diseases using pluripotent stem cells	Detail
Leader :	Akihide Kamiya

Proposed PRJ17	Functional analysis of the tumor suppressor APC in epithelial tubulogenesis and colorectal tumorigenesis	Detail
Leader :	Yoshihiro Kawasaki

Proposed PRJ18	3D analysis on the dynamic behavior of the biliary system under normal and liver injury conditions using a novel visualization technique	Detail
Leader :	Tohru Itoh

Proposed PRJ19	Molecular mechanism underlying the Hippo pathway-mediated three dimensional construction of the neural tube and blood vessel system	Detail
Leader :	Yoichi Asaoka

Proposed PRJ20	Role of Mob1 in epithelial tubular structure	Detail
Leader :	Akira Suzuki

Proposed PRJ21	Tubulogenesis in the embryonic kidney by cytoskeletal regulation	Detail
Leader :	Ryuichi Nishinakamura

Proposed PRJ22	Detection and elimination of malfunctioning cells in non-regenerative tissue	Detail
Leader :	Kiichiro Taniguchi

Proposed PRJ23	Molecular mechanism for aberrant tubular formation during intestinal carcinogenesis	Detail
Leader :	Toshiro Sato

Proposed PRJ24	Establishment of a cell invasion model and fluorescent imaging in organoid culture	Detail
Leader :	Etsuko Kiyokawa

Proposed PRJ25	Regulation of stem cell aging and its implication for functional decline of epithelial tubule tissues during aging process	Detail
Leader :	Kimi Yamakoshi

PAGE TOP